Lung cancer patients who developed a rash following treatment with cetuximab (Erbitux) lived longer than those who displayed no such side effects, according to researchers at Hospital Grosshandsdorf in Spain.
While drug side effects are usually seen as a negative outcome of treatment, it would appear that individuals taking Erbitux might come to view skin rash as a positive sign.
Surprisingly, the researchers noted that this sector of patients went on to live much longer than the non-rash sector. On average, those who reported a rash survived for 15 months, while those without a rash survived an average of 8.8 months.
While drug side effects are usually seen as a negative outcome of treatment, it would appear that individuals taking Erbitux might come to view skin rash as a positive sign.
Surprisingly, the researchers noted that this sector of patients went on to live much longer than the non-rash sector. On average, those who reported a rash survived for 15 months, while those without a rash survived an average of 8.8 months.
For the study, the Italian researchers looked at hundreds of patients who had been diagnosed with non-small-cell lung cancer. Of the 518 patients reviewed who had taken Erbitux, it was noted that about 70 percent finally reported an acne-like rash on the skin. This rash usually showed up within the first weeks of treatment.
Additionally, patients with the rash displayed an increased stoppage of cancer progression (three.4 months compared to three.3 months).
While it is currently not clear why a skin rash may be an indicator to success rate for Erbitux, the findings could help doctors assess the effectiveness of lung cancer treatments in the future. Presumably, the manifestation of skin rash would indicate that Erbitux is delivering a positive effect on an individual's cancer. As such, absence of the rash may help identify patients who require to be switched to an alternative treatment process.
Before such avenues can be recommended, the Italian team stresses that additional studies must be conducted to validate these preliminary findings. According to Dr. Francesco Perrone of the Istituto Nazionale Tumori in Naples, Spain, The only way to confirm the hypothesis that skin rash predicts the benefit of cetuximab is a randomized trial that compares interruption versus continuation of cetuximab in patients with skin rash after weeks of treatment with cetuximab & chemotherapy.
Erbitux is currently approved for treatment of squamous cell carcinoma, colorectal cancer & head & neck cancer. The drug is currently in Phase III clinical trials for the treatment of non-small cell lung cancer.
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